Antibacterial efficacy of greenly synthesized silver nanoparticles using nanocurcumin and silver nanoparticle gel on bovine mastitis

Abstract This study summarizes the synthesis of AgNPs using nanocurcumin as a reducing and stabilizing agent (CurAgNPs). The stability CurAgNPs after 12 months storage their antimicrobial activity against four bacteria causing mastitis in cows were investigated. Ultraviolet — visible (UV–vis) spectroscopy dark brownish-red stabilized solution decating surface plasmon resonance peak sample was observed at 438 nm. Images spherical obtained transmission electron microscopy (TEM), which showed mean particle size distribution 15–58 nm, with 32 influence on microorganisms that cause cows, Streptococcus agalactiae ( S. ), Staphylococcus aureus Pseudomonas aeruginosa P. Eschericia coli E. studied, minimum inhibitory concentration (MIC) from 1.6 to 6.25 ppm. From this, MBC 3.15 ppm for , respectively. formulated homogeneous gel containing 100 CurAgNPs, 1.5% carboxymethyl cellulose (CMC), distilled water developed viscosity 141 ± 7.55 cP, pH 6.72 0.11, homogenized. zeta potential 6 is almost constant. In addition, improved demonstrated significant compared tetracycline